OPTIMASI CARBOPOL 940 DAN GLISERIN PADA GEL TANAMAN ANTING-ANTING (Acalypha indica L.) SEBAGAI ANTIOKSIDAN

prayoga fery yuniarto(1*),

(1) 
(*) Corresponding Author

Abstract


Acalypha indica L. is suspected has an antioxidant. The use of anting-anting directly considered less practical, so that it made the gel preparations. And then it use optimation by Simplex Lattice Design method so get the most optimum antioxidant gel. This research purpose for know the efficacy of apple optimation gel as an antioxidant. Maceration extract made of gel with components carbopol 940(A) and glycerin(B) so that get three formulas, F1 (100%A), F2 (50%A, 50%B), dan F3 (100%B) and then optimation by viscosity, adhesion, and dispersive power. Simplex Lattice Design method with use program design- expert 8.0.6.1. Research antioxidant activity of optimum gel by method of DPPH. Antioxidant activity calculated by λ maximum and operating time so that get IC50 values by probit analysis. Optimation mixture between carbopol 940 and gliserin as components is carbopol 1,18 and glycerin 3,82. The resulted of t-test of viscosity, adhesion, and dispersive power showed no significant difference between the predictions with actual experimental result. The result showed optimum gel of apple fruit has antioxidant activity amounted to 164,58 ppm.

References


Aji Mukti R., Uji Aktivitas Antioksidan Pada Ekstrak Daging Lidah Buaya (Aloe Vera) Menggunakan Metode DPPH (1,1-Diphenyl-2-Picrylhidrazyl). UIN Syarif Hidayatullah. Jakarta, 2014.

Fitriana Yuli, Ittiqo’ D H., Optimasi Formula Gel Serbuk Daging Limbah Tomat (Lycopersicum Asculentum Mill) Dan Uji Ativitas Terhadap Lama Penyembuhan Luka Eksisi Pada Kelinci. Universitas Muhammadiyah Mataram: Jurnal Ulul Albab. Vol. 22 (1): 20-26, 2018.

Fitriansyah, S.N., Sohadi Wirya, Cici Hermayanti. Formulasi Dan Evaluasi Spray Gel Fraksi Etil Asetat Pucuk Daun Teh Hijau (Camelia Sinensis [L.] Kuntze) Sebagai Antijerawat. PHARMACY, Vol.13 No. 02 Desember 2016.

Halimah, N., Uji Fitokimia dan Uji Toksisitas Ekstrak Tanaman Anting-Anting (Acalypha indica L.) Terhadap Larva Udang Artemia salina Leach. Skripsi Tidak Diterbitkan. Malang: Jurusan Kimia Fakultas Sains dan Teknologi Universitas Islam Negeri Maulana Malik Ibrahim Malang, 2010.

Ismail, I, handayany G, Paturusi A, Ratnasari W, Formulasi Dan Uji Efektifitas Antioksidan Krim Ekstrak Etanol Korteks Kayu Jawa (Lannea Coromandelica Hout Merr) Dengan Metode Dpph, Jurnal Farmasi, Vo.2 No.3, 2014.

Lisdawati, V., Berdasar Uji Penampisan Farmakologi Pada Buah Mahkota Dewa. Fakultas Kedokteran. Yogyakarta: Universitas Gajahmada, 2002.

Molyneux, P., The Use Of The Stable Free Radical Diphenylpicrylhydrazyl (DPPH) For Estimating Antioksidan Activity, Songklanakarin: Journal Science Technology, 26: (2) 211-219, 2004.

Purwanto M, A N S P Swastika., Aktivitas Antioksidan Krim Ekstrak Sari Tomat (Solanum Lycopersicum L.). Universitas Gadjah Mada Yogyakarta Indonesia: Traditional Medicine Journal. Vol. 18 (3): 132-140, 2013.

Rahmadhani, Formulasi Sediaan Gel Ekstrak Ashitaba (Angelica Keiskei) Sebagai Antioksidan Dengan Kombinasi Gelling Agent Karbopol 940 Dan Cmc-Na Yang Diuji Dengan DPPH, 2017.

Rowe R., Sheskey P., Waller P., Handbook of Pharmaceutical Excipients, Edisi keempat. Washington DC: Pharmaceutical Press and American Pharmacist Associations,2006.

Sayuti, N, A., Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Daun Ketapang Cina (Cassia alata L.). Jurnal. Jurusan Jamu, Poltekes Kemenkes, Surakarta, 2015.

Voigt R., Buku Pelajaran Teknologi Farmasi. Edisi V., N. Soecandhi SN, Widianto MB. Penerjemah; Yogyakarta: Universitas Gajah Mada Press, terjemahan dari: Lerburch der Pharmaceutischen Technology,1995.

Yati, K,. Mahdi, J,. Misri,. Mardiastuti,. Lusi, P, D, Pengaruh Variasi Konsentrasi Hidroxy Methyl Cellulose (HPMC) Terhadap Stabilitas Fisik Gel Ekstrak Tembakau (Nikotiana tabacum L.) dan Aktivitasnya Terhadap Staphyllococcus aureus. Jurnal, Fakultas Farmasi dan Sains, Universitas Muhammadiyah Prof. DR. HAMKA. Jakarta,2018




DOI: http://dx.doi.org/10.30737/jafi.v2i1.1252

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